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目的:研究信号转导和转录激活因子3(STAT3)、磷酸化信号转导与转录激活因子3(p-STAT3)、缺氧诱导因子-1α(HIF-1α)、血管内皮细胞生长因子(VEGF)蛋白表达在肺癌侵袭与转移中的作用。方法:应用免疫组织化学方法检测66例肺癌组织及其癌旁组织中STAT3、p-STAT3、HIF-1α、VEGF蛋白表达情况。结果:STAT3、p-STAT3、HIF-1α、VEGF在肺癌组织中的表达明显高于癌旁组织;肺癌组织中它们之间的表达两两比较(秩和检验方法)均呈正相关,且与有无淋巴结转移和临床分期及分化程度有关,但与组织学类型、性别、年龄无关。结论:STAT3、p-STAT3、HIF-1α、VEGF可能在肺癌的发生发展、侵袭和转移中起重要的作用,抑制STAT3信号通路可望成为治疗非小细胞肺癌的治疗靶点。
OBJECTIVE: To study the effects of STAT3, p-STAT3, HIF-1α, VEGF (VEGF) on vascular endothelial growth factor ) Protein expression in invasion and metastasis of lung cancer. Methods: The expressions of STAT3, p-STAT3, HIF-1α and VEGF in 66 cases of lung cancer and adjacent normal tissues were detected by immunohistochemistry. Results: The expressions of STAT3, p-STAT3, HIF-1α and VEGF in lung cancer tissues were significantly higher than those in paracancerous tissues. The lung cancer tissues showed a positive correlation between them (rank sum test) No lymph node metastasis and clinical stage and degree of differentiation, but histological type, gender, age has nothing to do. Conclusion: STAT3, p-STAT3, HIF-1α and VEGF may play an important role in the development, invasion and metastasis of lung cancer. Inhibition of STAT3 signaling pathway is expected to become a therapeutic target for the treatment of non-small cell lung cancer.