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目的:应用瞬时波强(WI)技术结合缺氧诱导因子(HIF-1α)及血管内皮生长因子(VEGF)的变化,探讨高海拔低氧环境对急进高原地区的抗震官兵颈动脉弹性功能及相关细胞因子的影响。方法:选取100例急进高原地区7 d的抗震官兵(高原组)和100例平原健康官兵(对照组),应用WI技术检测两组官兵颈动脉包括压力-应变弹性系数(Ep)、硬化参数(β)、动脉顺应性(AC)、脉搏波反射增强(AI)、脉搏波传导速度(PWV-WI)在内的一系列弹性功能指标,同时检测血液中HIF-1α及VEGF的含量。结果:高原组的HIF-1α及VEGF较对照组均表达上调,PWV-WI增高(P<0.05)。两组间Ep、β、AC、AI无明显差异(P>0.05)。结论:高海拔低氧环境中HIF-1α和VEGF的表达上调可能对动脉弹性功能有调节作用,在反映颈动脉弹性功能的众多指标中,PWV-WI是急进高原地区缺氧反应的敏感指标。
Objective: To investigate the effects of high altitude and low oxygen environment on the elastic function of anti-shake officers and men’s carotid arteries in rapid plateau by using the combination of instantaneous wave intensity (WI) and hypoxia inducible factor (HIF-1α) and vascular endothelial growth factor (VEGF) Effects of cytokines. Methods: 100 earthquake-resistant officers and soldiers (plateau group) and 100 healthy plain soldiers (control group) in 7 days were selected. The WI technique was used to detect the carotid arteries including the stress-strain elastic modulus (Ep) β, Arterial Compliance (AC), Pulse Wave Reflectance (AI) and Pulse Wave Velocity (PWV-WI) were measured. The levels of HIF-1α and VEGF in the blood were also measured. Results: The expression of HIF-1α and VEGF in plateau group were both up-regulated and PWV-WI were increased (P <0.05). There was no significant difference in Ep, β, AC, AI between the two groups (P> 0.05). CONCLUSION: Upregulation of HIF-1α and VEGF in high altitude and hypoxia may play an important role in the regulation of arterial elasticity. PWV-WI is a sensitive indicator of acute hypoxia in the plateau, reflecting many indicators of carotid artery elasticity.