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目的:探讨C-erBb-2和P53表达与宫颈鳞癌生物学行为的关系。方法:应用免疫组化SP法研究54例宫颈鳞癌C-erBb-2和P53表达。结果:在宫颈鳞癌中C-erBb-2的阳性表达率为27.78%、P53阳性表达率为29.63%。C-erBb-2和P53的表达与年龄、临床分期无显著性差异(P>0.05)、但两者与淋巴结转移有显著性差异(P<0.05)。C-erBb-2和P53两者在宫颈鳞癌中的表达无显著性差异(P>0.05)。结论:C-erBb-2和P53与宫颈鳞癌的分化及转移密切相关,可用与判断宫颈鳞癌的预后。
Objective: To investigate the relationship between the expression of C-erBb-2 and P53 and the biological behavior of cervical squamous cell carcinoma. Methods: The expressions of C-erBb-2 and P53 in 54 cases of cervical squamous cell carcinoma were studied by immunohistochemical SP method. Results: The positive rate of C-erBb-2 in cervical squamous cell carcinoma was 27.78% and the positive rate of P53 was 29.63%. The expression of C-erBb-2 and P53 had no significant difference with age and clinical stages (P> 0.05), but there was significant difference between them (P <0.05) and lymph node metastasis. The expression of C-erBb-2 and P53 in cervical squamous cell carcinoma had no significant difference (P> 0.05). Conclusion: C-erBb-2 and P53 are closely related to the differentiation and metastasis of cervical squamous cell carcinoma, which can be used to judge the prognosis of cervical squamous cell carcinoma.