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目的探讨普鲁卡因青霉素与苄星青霉素治疗妊娠梅毒患者的妊娠结局不良率及随诊率有无差异。方法收集2009年3月至2011年3月门诊159例妊娠梅毒患者,根据患者处理方式的不同,分组进行比较。结果 A组为普鲁卡因青霉素治疗组,有效病例53例,普鲁卡因青霉素80万单位肌肉注射,每日1次,连续15日;B组为苄星青霉素治疗组,有效病例75例,苄星青霉素240万单位肌肉注射,每周1次,连续3周;C组为未治疗组,有效病例9例,D组为快速血浆反应素环状卡片试验(RPR)及梅毒螺旋体血球凝集试验(TPHA)均阴性的正常孕妇159例。A、B、C、D组妊娠结局异常率分别为18.87%(10/53)、17.33%(13/75)、66.67%(6/9)、15.72%(25/159),C、D组间,A、C组间,B、C组间差异均有统计学意义;A、D组间,B、D组间,A、B组间,差异均无统计学意义。A、B组随诊率分别为76.81%、92.59%,两组间随诊率差异有统计学意义。结论未治疗组妊娠梅毒的妊娠结局不良率远高于治疗组及正常孕妇组,治疗组的妊娠结局不良率与正常孕妇组无明显差异,且2种青霉素治疗组间无明显差异,但2治疗组间随诊率有差异。
Objective To investigate whether there is difference between the rate of pregnancy outcome and the follow-up rate of procaine penicillin and benzathine penicillin in the treatment of pregnant women with syphilis. Methods A total of 159 outpatients with pregnancy syphilis from March 2009 to March 2011 were collected and compared according to different treatment methods. Results A group of procaine penicillin treatment group, 53 cases of effective, procaine penicillin 800 000 units intramuscularly, once daily for 15 days; B group of benzathine penicillin treatment group, 75 cases of effective cases , And 2.40 million units of benzathine penicillin were intramuscularly injected once a week for 3 weeks. Group C was untreated, and 9 cases were effective. Group D was a rapid plasmaprorein cyclic card test (RPR) and treponema pallidum The test (TPHA) were negative in normal pregnant women 159 cases. The abnormal rates of pregnancy outcomes in groups A, B, C and D were 18.87% (10/53), 17.33% (13/75), 66.67% (6/9), 15.72% (25/159) There was no significant difference between group A, group C, group B, and group C; There was no significant difference between group A, group D, group B, group D, group A, and group B. The follow-up rates of group A and group B were 76.81% and 92.59%, respectively. There was significant difference in the follow-up rate between the two groups. Conclusion The non-treatment pregnancy rate of syphilis in pregnant women is much higher than that in the treatment group and the normal pregnant women. There is no significant difference in the pregnancy outcome between the treatment group and the normal pregnant women, but there is no significant difference between the two penicillin treatment groups. However, There was a difference in follow-up rates between groups.