本病是发生于妊娠晚期罕见的一种妊娠合并症,近年来发病率有所增加。病变以肝脏的脂肪变性为主。临床表现有恶心、呕吐、腹痛、黄疸、出血、进行性肝肾衰竭、神志障碍、昏迷,常死于肝外并发症。虽然本病是一危重病症,但如能早期诊断可以改善其预后。本文对该病的病因、病理、临床表现、实验室检查、诊断、产科处理等作一介绍。 一、发病情况 发病率低于万分之一,有人报告约一百万孕妇中有一名,有人报告约13,328名产妇中有一名,至今世界英文文献报告仅约100例,国内已有15例报告。 二、病因 本病病因末明,可能与妊娠中激素的异常、营养障碍、妊娠中毒症、胎儿因素、代谢障碍、环境因素等有关。本病合并妊娠中毒症高达22～40％,肝组织一般呈轻至中等损害,并呈亚 The disease is rare in pregnancy occurred in a pregnancy complications, the incidence in recent years has increased. Lesions in the liver of the main fatty degeneration. Clinical manifestations of nausea, vomiting, abdominal pain, jaundice, bleeding, progressive liver and kidney failure, psychiatric disorders, coma, often died of extrahepatic complications. Although this disease is a critical illness, early diagnosis can improve its prognosis. This article introduces the etiology, pathology, clinical manifestations, laboratory tests, diagnosis, obstetric treatment of the disease. First, the incidence of morbidity less than one ten thousandth, it was reported that about one million pregnant women, one was reported that about 13,328 mothers in one, so far the world’s English literature reports only about 100 cases, there are 15 cases of domestic reports . Second, the cause of the disease The end of the Ming may be related to abnormal hormones in pregnancy, nutritional disorders, gestosis, fetal factors, metabolic disorders, environmental factors. The disease complicated with gestosis poisoning up to 22 ~ 40%, liver tissue generally mild to moderate damage, and was sub