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目的：探讨血清瘦素(Leptin),胰岛素(INS),胰岛素抵抗指数(IRI)．肿瘤坏死因子α(TNF-α),超氧化物岐化酶(SOD)浓度变化对NAFLD诊断及预后判断的临床应用价值。方法：采用放射免疫法检测Leptin、INS、TNF-α,化学法检测SOD,根据HOMA-IR-[FBG(mmol/l)×FIN(mIU/l)]/22．5计算胰岛素抵抗指数(IRI)。结果：①NASH组32例瘦素浓度(13．320±5．323ng/ml)显著高于NASFL组32例(8．068±2．320ng/ ml)(P＜0．05)和NC组32例(3．533±1．686ng/ml)(P＜0．05),NASFL组32例瘦素浓度显著高于NC组(P＜0．05)。②NASH组INS浓度(24．810±9．01 7mIU/l)及IRI(6．733±2．501)显著高于NC组(15．460±6．012mIU/l,4．131±2．158)(P＜0．05),NASFL组INS浓度(21．180±11．610mIU/l)及IRI(6．462±2．872)显著高于NC组(P＜0．05),NASH组INS浓度及IRI与NASFL组比较差异无显著性(P＞0．05)。③NASH组TNF-α浓度(0．322±0．165ng/ml)显著高于NC组(0．254±0．093ng/ml)(P＜0．05)．NASH组与NASFL组TNF-α浓度(0．271±0．098ng/ml)比较差异有显著性(P＜0．05),NASFL组与NC组TNF-α浓度比较差异无显著性(P＞0．05)。④NC组SOD浓度(112．200±7．978U/ml)显著高于NASH组(72．540±1．32U/ml)(P＜0．05),NASFL组SOD浓度(109．900±8．903U/ml)显著高于NASH组(P＜0．05),NASFL组与NC组SOD浓度比较差异无显著性(P＞0．05)。结论：联合检测血清Leptin、INS、TNF-α、SOD对NAFLD的诊断及预后判断具有一定的临床参考价值。
Objective: To investigate the serum leptin, insulin and insulin resistance index (IRI). The Clinical Value of the Changes of Tumor Necrosis Factor α (TNF-α) and Superoxide Dismutase (SOD) in the Diagnosis and Prognosis of NAFLD. Methods: Leptin, INS and TNF-α were detected by radioimmunoassay and SOD was detected by chemical method. Insulin resistance index (IRI) was calculated according to HOMA-IR- [FBG (mmol / l) × FIN (mIU / l)] /22.5 ). Results: ① The 32 leptin concentrations (13.320 ± 5.323 ng / ml) in NASH group were significantly higher than those in NASFL group (32.68 ± 2.320 ng / ml) and 32 (3.533 ± 1.686ng / ml) (P <0.05). The concentration of leptin in NASFL group was significantly higher than that in NC group (P <0.05). ② The INS concentration (24.810 ± 9.01 7mIU / l) and IRI (6.733 ± 2.501) in NASH group were significantly higher than those in NC group (15.460 ± 6.012mIU / l, 4.131 ± 2.158 (P <0.05). The INS concentrations in NASFL group (21.180 ± 11.610mIU / l) and IRI (6.462 ± 2.872) were significantly higher than those in NC group (P <0.05) There was no significant difference in INS concentration and IRI between NASFL group and NASFL group (P> 0.05). ③ The concentration of TNF-α in NASH group (0.322 ± 0.165ng / ml) was significantly higher than that in NC group (0.254 ± 0.093ng / ml) (P <0.05). TNF-α concentration in NASH group and NASFL group was significantly lower than that in NASFL group (0.271 ± 0.098ng / ml) (P <0.05), but there was no significant difference between NASFL group and NCFL group (P> 0.05). ④ The SOD concentration in NC group (112.200 ± 7.978U / ml) was significantly higher than that in NASH group (72.540 ± 1.32U / ml) (P <0.05). The SOD concentration in NASFL group (109.900 ± 8. 903U / ml) was significantly higher than that of NASH group (P <0.05). There was no significant difference in SOD level between NASFL group and NC group (P> 0.05). Conclusion: The combined detection of serum Leptin, INS, TNF-α and SOD has certain clinical value in the diagnosis and prognosis of NAFLD.