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有报道噻嗪类利尿剂能诱发糖尿病或降低糖耐量;诱发低钾血症及降低体内钾含量;升高血清尿酸浓度及增加发生痛风的危险。本文报道106例轻度到中度高血压的中年男性患者,随机等分为两组,分别应用苄氟噻嗪(bendroflumethiazide)或心得安(propranolol)治疗6年期间的抗高血压效果和代谢变化。结果治疗前两组间血压无明显差别。治疗1年后两组收缩压和舒张压均明显降低,并且任何时间两组间收缩压或舒张压均无明显差别。治疗前两组患者心率均为86次,治疗后苄氟噻嗪组无变化,而心得安组第1年内明显下降,且整个随访期间保持于此水平
It is reported that thiazide diuretics can induce diabetes or reduce glucose tolerance; induce hypokalemia and reduce the body potassium content; increase serum uric acid concentration and increase the risk of gout. This article reports 106 middle-aged male patients with mild to moderate hypertension were randomly divided into two groups were treated with bendroflumethiazide (bendroflumethiazide) or propranolol (propranolol) for 6 years of antihypertensive effect and metabolism Variety. Results There was no significant difference in blood pressure between the two groups before treatment. Systolic blood pressure and diastolic blood pressure were significantly reduced in both groups after 1 year of treatment, and there was no significant difference in systolic or diastolic blood pressure between the two groups at any time. Before treatment, the heart rate of the two groups were 86, and there was no change in the bendroflumethiazide group after treatment, but the level of propranolol decreased significantly in the first year and maintained at this level during the follow-up period