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目的观察雷贝拉唑、奥美拉唑治疗老年性反流性食管炎的临床疗效。方法选取医院就诊的反流性食管炎患者80例,根据患者入院编号进行平均分组,其中单号为试验组,双号为对照组,每组40例。对照组给予奥美拉唑治疗,试验组给予雷内拉唑治疗。由同一医护人员对患者治疗后第1、2、3天及1、2、3周进行随访,观察治疗效果;治疗后第4、8周进行胃镜复查。结果试验组治疗总有效率为92.5%,高于对照组的82.5%(P<0.05)。胃镜复查显示:在第4周时,试验组38例(95.0%)得到治愈和好转,高于对照组的30例(75.0%),差异有统计学意义(P<0.05);但在第8周时,2组患者胃镜行复查比较差异无统计学意义(P>0.05)。结论老年性反流性食管炎应用雷贝拉唑治疗效果确切,值得临床推广应用。
Objective To observe the clinical efficacy of rabeprazole and omeprazole in the treatment of senile reflux esophagitis. Methods Eighty patients with reflux esophagitis were selected according to the hospital admission number. The single number was the test group and the double number was the control group with 40 cases in each group. The control group was treated with omeprazole, and the experimental group was given levoprazole. Patients were treated by the same medical staff 1, 2, 3 days and 1,2,3 weeks were followed up to observe the effect of treatment; 4,8 weeks after treatment gastroscopy. Results The total effective rate of the experimental group was 92.5%, which was higher than that of the control group (82.5%, P <0.05). Gastroscopy review showed that in the fourth week, 38 cases (95.0%) in the experimental group were cured and improved, which was higher than that in the control group (75.0%), the difference was statistically significant (P <0.05) Weeks, two groups of patients underwent endoscopy retrospective examination showed no significant difference (P> 0.05). Conclusion The treatment of senile reflux esophagitis with rabeprazole is effective and worthy of clinical application.