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目的:探讨半夏泻心汤对脾虚便秘小鼠血常规的影响。方法:将24只实验小鼠随机分成正常组、模型组、枳术汤组和半夏泻心汤组,除正常组外,其余各组灌胃番泻叶水煎液,7天后控制饮食,饥饱失常8天,构建小鼠脾虚便秘模型。造模结束后,半夏泻心汤组、枳术汤组分别采用半夏泻心汤和枳术汤灌胃,模型组和正常组均灌胃蒸馏水,共6天,治疗结束后进行血常规指标检测。结果:与正常组比较,模型组白细胞计数(WBC)、中性粒细胞计数(NEUT)显著降低,差异均有统计学意义(P<0.01,P<0.05)。与模型组比较,半夏泻心汤组血小板计数(BPC)、血小板平均压积(PCT)、红细胞平均血红蛋白含量(MCH)、WBC、NEUT、淋巴细胞计数(LYM)显著升高,红细胞分布宽度(RDW)降低,差异均有统计学意义(P<0.05);与枳术汤组比较,半夏泻心汤组BPC、PCT、WBC、NEUT、LYM升高更明显,差异均统计学意义(P<0.05)。结论:半夏泻心汤能促进脾虚便秘小鼠血小板计数、血小板平均压积、红细胞平均血红蛋白含量、白细胞计数、中性粒细胞计数和淋巴细胞计数的恢复,有利于血液功能的调节。
Objective: To investigate the effect of Banxiaxiexin Decoction on the blood routine of spleen-asthenia constipation mice. Methods: Twenty-four experimental mice were randomly divided into normal group, model group, Zhizhu Decoction group and Banxiaxiexin Decoction group, except the normal group, the other groups were infused with senna decoction, control diet after 7 days, Hungry for 8 days, to construct mouse constipation model of spleen deficiency. After the modeling, the Banxiaxiexin Decoction group and the Zhizhu Decoction group were respectively fed with Banxiaxiexin Decoction and Zhizhu Decoction, and the model group and the normal group were fed with distilled water for 6 days. After the treatment, the blood routine Indicator detection. Results: Compared with the normal group, the WBC and NEUT of the model group decreased significantly (P <0.01, P <0.05). Compared with the model group, BPC, PCT, MCH, WBC, NEUT and LYM were significantly increased, and the distribution width of red blood cells (P <0.05). The BPC, PCT, WBC, NEUT and LYM increased significantly in Banxiaxiexin Decoction group compared with Zhizhu Decoction group (P <0.05), and the difference was statistically significant P <0.05). Conclusion: Banxiaxiexin Decoction can promote the recovery of platelet count, mean platelet pressure, average hemoglobin content, white blood cell count, neutrophil count and lymphocyte count in mice with spleen asthenia constipation, which is beneficial to the regulation of blood function.