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N 磷酰化氨基酸在温和条件下即可发生磷上酯交换反应、羧基上的酯化反应、与氨基酸反应成肽及与核苷反应形成聚核苷酸等 .这些化学性质在生命起源研究中具有重要意义 .最近的研究表明 :分子内磷酸羧酸混酐可能是这几类反应的共同中间体 ,这类中间体性质活泼难以从反应中直接观察到 .用MNDO方法对N 二异丙基磷酰 L 丙氨酸 (DIPP Ala)形成分子内混酐的反应机理研究表明 :这一反应为非同步的协同反应 ,经过一种含有氢桥键结构的过渡态 .氢桥键的存在使反应过渡态能量较低 .理论计算对五配位磷中间体的形成过程、结构特点及促进N 磷酰化氨基酸的多种反应活性的能力进行了成功的解释 .
N phosphorylation of amino acids under mild conditions can occur phosphorus transesterification, carboxyl esterification reaction with amino acids into peptides and react with nucleosides to form polynucleotides, etc. These chemical properties in the study of the origin of life Is very important.Recent studies have shown that: intramolecular phosphonic acid carboxylic anhydride mixed may be the common intermediate of these types of reactions, the nature of these intermediates is difficult to directly observed from the reaction.MNDO method for N diisopropyl The reaction mechanism of intramolecular mixed anhydride of phosphoryl L-alanine (DIPP Ala) shows that this reaction is a non-synchronous synergistic reaction through a transition state containing hydrogen bridge. The existence of hydrogen bridge makes the reaction The energy of the transition state is relatively low. The theoretical calculations have successfully explained the formation process, structural characteristics and the ability to promote the various reactivity of N-phosphorylated amino acids.