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目的 研究电穿孔技术对小分子离子型药物经皮渗透的影响。方法 以盐酸丁卡因为小分子离子型模型药物 ,使用双室扩散池方法研究电穿孔对其在离体大鼠腹部皮肤经皮渗透的影响 ,并与被动扩散和离子导入进行比较。结果 外加电脉冲 (方波脉冲 ,脉冲幅度为 130V ,脉冲宽度为 0 .4s,脉冲率为 40pulses·min-1)后 ,盐酸丁卡因的渗透速率较被动扩散增加 3.5倍以上 ,比离子导入 (0 .2mA·cm-2 ,4h)增加 1倍以上 ;并且渗透速率随着脉冲数的增加而增加。结论 电穿孔技术能明显地促进小分子离子型药物盐酸丁卡因的经皮渗透。
Objective To study the effect of electroporation on transdermal permeation of small molecule ionic drugs. Methods The effect of electroporation on percutaneous penetration of abdominal skin in isolated rat was studied using tetracaine hydrochloride as a model drug for small molecule ion model and double diffusion cell method. The results were compared with passive diffusion and iontophoresis. Results Compared with passive diffusion (tetragonal pulse, pulse width 130V, pulse width 0s. 4s, pulse rate 40pulses · min-1), the permeation rate of tetracaine hydrochloride was 3.5 times more than that of passive diffusion (0.2mA · cm-2, 4h) increased more than 1 times; and the penetration rate increased with the increase of pulse number. Conclusion Electroporation technology can significantly promote the transdermal penetration of small molecule ionic drug tetracaine hydrochloride.