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目的:研究苍藿平胃颗粒对慢性胃炎及胆汁返流性胃炎的治疗作用。方法:建立大鼠慢性胃炎模型和胆汁返流性胃炎模型,分组给药治疗1 w后取其标本,检测胃液量、胃液酸度及胃蛋白酶活性,并观察其病理学变化。结果:苍藿平胃颗粒中、高剂量对慢性胃炎和胆汁返流性胃炎大鼠胃酸度的降低有明显抑制作用;病理检查显示,苍藿平胃颗粒低、中、高剂量对慢性胃炎和胆汁返流性胃炎大鼠的胃黏膜病理组织学有显著改善作用。结论:苍霍平胃颗粒对慢性浅表性胃炎、胆汁返流性胃炎具有一定的保护作用。
Objective: To study the therapeutic effect of gianhuo pingwei granule on chronic gastritis and bile reflux gastritis. Methods: Chronic gastritis model and bile reflux gastritis model were established in rats. The rats were sacrificed after 1 w of treatment. The gastric juice volume, gastric acidity and pepsin activity were measured and pathological changes were observed. Results: Gianguoping Pingwei Granules, high doses of chronic gastritis and bile reflux gastritis rat gastric acidity decreased significantly inhibited; pathological examination showed that Grifola pelagic stomach particles low, medium and high doses of chronic gastritis and Gastric mucosal histopathology in rats with bile regurgitant gastritis has a significant improvement. Conclusion: Cough Huping granules on chronic superficial gastritis, bile reflux gastritis have some protective effect.