目的　建立简便易行、重复性好、无创伤、符合人类发病条件的ＶＢＥ 新模型。方法　Ｗｉｓｔａｒ鼠腹腔注射苯肾上腺素，测定微血管通透性，测量脑灰、白质水分含量，组织病理证实脑水肿。结果　血脑屏障通透性增高，脑水分增加（Ｐ＜ ０．０１），灰质水分增加１１．６１％ ，白质水分增加１４．６４％ ，白质比灰质水分增加明显（Ｐ＜ ０．０５）。结论　注射苯肾上腺素制成ＶＢＥ动物模型，操作简便、无创伤、重复性好。 Objective To establish a new model of VBE that is easy to operate, repeatable, non-invasive and meets the requirements of human disease. Methods Wistar rats were injected intraperitoneally with phenylephrine, the microvascular permeability was measured, the content of brain gray matter and white matter were measured, and the histopathology confirmed the brain edema. Results The permeability of the blood-brain barrier increased and the brain water increased (P <0.01). The gray matter moisture increased by 11.61%, the white matter moisture increased by 14.64%, and the white matter-to-gray matter moisture increased significantly (P <0.05). Conclusion Injection of phenylephrine into animal models of VBE, easy to operate, non-invasive, good repeatability.