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目的探讨胰岛素强化方法治疗成人隐匿性自身免疫性糖尿病老年患者的疗效及其对胰岛β细胞功能的影响。方法选取36例成人隐匿性自身免疫性糖尿病老年患者作为观察组,同期35例老年2型糖尿患者者作为对照组,两组患者均予以胰岛素强化方法治疗,观察比较两组治疗效果以及胰岛β细胞功能变化情况。结果治疗前两组血糖以及糖化血红蛋白(Hb Alc)水平比较差异无统计学意义(P>0.05);治疗后两组血糖以及Hb Alc水平均明显低于治疗前,差异有统计学意义(P<0.05),但对照组与观察组比较差异无统计学意义(P>0.05)。对照组治疗前胰岛素释放指数(HOMA-IS)为(3.7±0.6),治疗后为(4.4±1.2);观察组治疗前HOMA-IS为(2.3±0.6),治疗后为(3.5±1.0);两组治疗后HOMA-IS低于治疗前,差异均具有统计学意义(P<0.05)。结论胰岛素强化方法治疗成人隐匿性自身免疫性糖尿病老年患者疗效确切,且能够提高胰岛β细胞功能,值得推广。
Objective To investigate the effects of insulin-potentiation on senile patients with latent autoimmune diabetes in adults and its effects on the function of islet β-cells. Methods Thirty-six elderly patients with occult autoimmune diabetes mellitus were selected as the observation group and 35 elderly patients with type 2 diabetes mellitus as the control group. All patients were treated with insulin-enhanced therapy. The therapeutic effects and the effects of pancreatic β-cell Functional changes. Results There was no significant difference in blood glucose and Hb Alc level between the two groups before treatment (P> 0.05). The levels of blood glucose and Hb Alc in the two groups after treatment were significantly lower than those before treatment (P < 0.05), but there was no significant difference between the control group and the observation group (P> 0.05). The HOMA-IS before treatment was (3.7 ± 0.6) in control group and (4.4 ± 1.2) after treatment. HOMA-IS was (2.3 ± 0.6) before treatment and (3.5 ± 1.0) after treatment in observation group ; HOMA-IS after treatment was lower than before treatment, the difference was statistically significant (P <0.05). CONCLUSION: Insulin-potentiating therapy is effective in elderly patients with latent autoimmune diabetes in adults and can improve the function of pancreatic β-cells. It is worth promoting.