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Objective: To report a case of androstenedione (A)-induced impotence and severe oligospermia. Design: Case report. Setting: Multispecialty tertiary referral center. Patient(s): A 29-year-old married male recreational bodybuilder using the legal dietary supplement A in an attempt to enhance athletic performance. Intervention(s): Immediate cessation of oral A, Depo-T regimen with a taper, administered during 3 months, to alleviate loss of libido and impotence. Main Outcome Measure(s): Resolution of symptoms and normalization of semen parameters. Result(s): Resolution of symptoms and normalization of semen parameters at 6 months, and successful intrauterine pregnancy achieved 1 year after initial presentation. Conclusion(s): Oral A has a previously unrecognized side effect, which is the potential to suppress the hypothalamic pituitary gonadal axis.
Objective: To report a case of androstenedione (A) -induced impotence and severe oligospermia. Design: Case report. Setting: Multispecialty tertiary referral center. Patient (s): A 29-year-old married male recreational bodybuilder using the legal dietary supplement A in an attempt to enhance athletic performance. Intervention (s): Immediate cessation of oral A, Depo-T regimen with a taper, administered during 3 months, to alleviate loss of libido and impotence. Main Outcome Measure (s): Resolution of Results (s): Resolution of symptoms and normalization of semen parameters at 6 months, and successful intrauterine pregnancy achieved 1 year after initial presentation. Conclusion (s): Oral A has a previously unrecognized side effect, which is the potential to suppress the hypothalamic pituitary gonadal axis.