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蛋白质在细胞中的定位和分布非常重要,蛋白质的错误定位或者异常调节将会导致各种疾病的产生,包括癌症、炎症、自身免疫性疾病等。XPO1(又称CRM1)是核输出蛋白受体importinβ家族的重要成员,主要负责一些肿瘤抑制蛋白、生长调节蛋白如p53、p21、FOXO、PI3K/AKT、Wnt/β-catenin、AP-1和NF-κB等的核输出,通过小分子化合物来调节XPO1介导的特异性蛋白质的核输出,从而恢复一些重要蛋白质在核内的正常分布及功能,是治疗相关疾病的一种有效方法。本综述介绍XPO1介导的核输出机制以及靶向核输出蛋白XPO1治疗疾病的研究进展。
Protein localization and distribution in the cell is very important, wrong localization of protein or abnormal regulation will lead to a variety of diseases, including cancer, inflammation, autoimmune diseases. XPO1, also known as CRM1, is an important member of the importinβ family of nuclear export protein receptors and is responsible for several tumor suppressor proteins such as p53, p21, FOXO, PI3K / AKT, Wnt / β-catenin, AP-1 and NF -κB and other nuclear export, through the small molecule compounds to regulate XPO1-mediated nuclear export of specific proteins in order to restore the normal distribution of some important proteins in the nucleus and function, is an effective treatment for related diseases. This review presents the advances in the mechanisms of XPO1-mediated nuclear export and targeting of the nuclear export protein XPO1.