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目的:探讨Survivin原位杂交表达在宫颈癌及癌前病变诊断中的应用效果。方法:宫颈癌患者45例作为观察组,另取宫颈上皮内瘤变45例作为对照Ⅰ组、正常宫颈组织45例作为对照Ⅱ组,所有研究对象给予Survivin原位杂交检测。结果:Survivin在对照Ⅱ组、对照Ⅰ组、观察组表达阳性率分别为2.2%、48.9%和84.4%,组间对比差异有统计学意义(P<0.05)。Survivin在宫颈癌Ⅰ期、Ⅱ期和Ⅲ期的阳性表达率对比差异有统计学意义(P<0.05)。Survivin在宫颈癌高分化组、中分化组及低分化组的阳性表达率对比差异也有统计学意义(P<0.05)。Survivin的表达与淋巴结转移无关(P>0.05)。结论:Suvrvini可在宫颈癌及癌前病变的发生发展中发挥作用,其Survivin表达程度与病期进展和不良组织学分级相一致,可作为预后不良的标志之一。
Objective: To investigate the application of Survivin in situ hybridization in the diagnosis of cervical cancer and precancerous lesions. Methods: Forty-five patients with cervical cancer were selected as the observation group. Another 45 patients with cervical intraepithelial neoplasia were selected as control group Ⅰ and 45 cases of normal cervical tissue as control group Ⅱ. Survivin in situ hybridization was performed in all subjects. Results: The positive rates of Survivin in control group Ⅱ and control group Ⅰ were 2.2%, 48.9% and 84.4% respectively. The difference between the two groups was statistically significant (P <0.05). The positive rates of Survivin in stage Ⅰ, Ⅱ and Ⅲ of cervical cancer were significantly different (P <0.05). The positive rate of survivin expression in well differentiated group, moderately differentiated group and poorly differentiated group was also significantly different (P <0.05). The expression of Survivin had no correlation with lymph node metastasis (P> 0.05). Conclusion: Suvrvini can play a role in the development of cervical cancer and precancerous lesions. The expression of Survivin is consistent with the stage of progression and the histological grade, which may be one of the markers of poor prognosis.