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血流中的外源性微粒被网状内皮系统排赊而集中于肝、脾和骨髓,是一种已知的生理现象.因此我们设想:将不溶于水的抗癌药物制成混悬剂或胶体,作静脉注射对治疗肝癌和白血病可能效果更佳.现在临床所用的抗癌药物喜树碱钠盐系将喜树碱的内脂环打开的衍生物,其生物活性不能代表喜树碱本身.以前国內外均使用喜树碱钠盐作静脉注射以治疗恶性肿瘤,有一定疗效,但毒性反应较大.且对原发性肝癌和白血病疗效不
Exogenous microparticles in the bloodstream are repelled by the reticuloendothelial system and concentrated in the liver, spleen, and bone marrow. This is a known physiological phenomenon. Therefore, we envisage that suspensions should be made of water-insoluble anticancer drugs. Or colloids, intravenous injection for the treatment of liver cancer and leukemia may be better. Now the clinical use of the anticancer drug camptothecin sodium salt is the opening of the camptothecin inner alicyclic derivatives, its biological activity can not represent camptothecin In itself, the use of camptothecin sodium salt for intravenous injection at home and abroad has been used for the treatment of malignant tumors. It has a certain effect, but it has a high toxicity and is not effective for primary liver cancer and leukemia.