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报告2例多年前曾意外发生农药林丹中毒(在同一实验室工作时发生),分别于中毒后第23年、26年确诊多发性骨髓瘤。血清有机氯农药及代谢产物水平与乳腺癌、子宫颈癌、子宫肌瘤发病率呈正相关;有些农药具有类似生物体激素性质,扰乱生物体内分泌系统作用。农药致癌发病率上升可能包括DNA损伤,损伤基因的固定和增殖,包括内分泌干扰物影响,影响免疫功能等。多发性骨髓瘤发生、发展与肺、肾密切相关,肺金受损,波及肾水,母病及子。化疗同时联合中药内服,补益肺肾、活血解毒、增效减毒。挖掘中西医综合诊疗,为多发性骨髓瘤研究提供新的思路,为预防医学提供新的参考信息。
Two cases of accidental pesticide Lindane poisoning (occurring while working in the same laboratory) were reported in two cases many years ago. Multiple myeloma was diagnosed at 23 and 26 years after poisoning respectively. Serum levels of organochlorine pesticides and metabolites are positively correlated with the incidence of breast cancer, cervical cancer and uterine fibroids. Some pesticides have the similar characteristics of biological hormones and disturb the function of the organism’s endocrine system. The rising incidence of pesticide carcinogenesis may include DNA damage, injury gene fixation and proliferation, including the impact of endocrine disruptors, affecting immune function. Multiple myeloma, development and lung, kidney are closely related, lung gold damage, affecting kidney water, mother and child. Chemotherapy combined with traditional Chinese medicine orally, replenishing lung and kidney, promoting blood circulation and detoxification, increasing efficiency and attenuating. Excavating the integrated diagnosis and treatment of traditional Chinese and western medicine provides new ideas for the study of multiple myeloma and provides new reference information for preventive medicine.