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本文报道狗急性出血坏死性胰腺炎时血清、肺淋巴液和支气管肺泡灌洗液的磷酸酶A_2(PLA_2)活性升高,肺淋巴流量和跨肺蛋白清除率增大;支气管-肺泡灌洗液内蛋白浓度和细胞数量增加;血清、肺淋巴液和肺匀浆脂质过氧化物增多;形态学检查显示严重的肺水肿和局灶性肺不张。预先给予PLA_2抑制剂氯喹可阻断上述变化。首先发现PLA_2可使肺微血管通透性升高,PLA_2活性升高是导致急性胰腺炎时肺水肿的主要因素。
In this paper, the activity of phosphatase A_2 (PLA_2) in serum, lung lymph and bronchoalveolar lavage fluid of acute hemorrhagic necrotizing pancreatitis was increased, the pulmonary lymphatic flow and trans-pulmonary protein clearance increased; bronchoalveolar lavage fluid Increased protein concentration and cell number; increased lipid peroxides in serum, lung lymph, and lung homogenates; and morphological examination revealed severe pulmonary edema and focal atelectasis. Preincubation with chloroquine, a PLA_2 inhibitor, blocked these changes. PLA2 first found that pulmonary microvascular permeability increased PLA2 activity is the leading cause of pulmonary edema in acute pancreatitis, the main factor.