用聚合酶反应－单链构象多态分析法对３０例肺癌的Ｐ５３基因突变进行了观察。对第５、６、７、８四个高变异区进行了检测，发现２０例有Ｐ５３基因突变（６６％），其中鳞癌１２例，有８例检出Ｐ５３基因突变（６６．６％）；转移性腺癌８例，检出６例有Ｐ５３基因突变（７５％）；４例未分化癌亦有此突变；尚有４例癌性胸水，其中２例找到Ｐ５３基因突变。本文讨论了Ｐ５３基因突变与预后的关系。 Polymerase reaction-single strand conformation polymorphism analysis was used to observe the mutation of P53 gene in 30 lung cancer patients. Five high-variant regions No. 5, No. 6, No. 7, and No. 8 were detected and found to have P53 mutations (66%) in 20 cases, including 12 cases of squamous cell carcinoma and 8 cases of P53 mutation (66.6%). Metastatic adenocarcinoma was found in 8 cases, and 6 cases had P53 gene mutation (75%); 4 cases of undifferentiated carcinoma also had this mutation; 4 cases had malignant pleural effusion, and 2 cases found P53 gene mutation. This article discusses the relationship between mutations in P53 and prognosis.