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目的探讨血清高敏C反应蛋白(hs-CRP)、大内皮素-1(bigET-1)及尿酸水平的变化与老年原发性高血压患者伴下肢动脉硬化症的关系。方法老年单纯高血压病组、高血压并下肢动脉硬化组及对照组各35例,分别测定hs-CRP、bigET-1及尿酸在各组血清中的浓度变化,对其结果进行统计分析。结果高血压并下肢动脉硬化组hs-CRP、bigET-1及尿酸水平明显高于单纯高血压病组及对照组,3组间的比较差异有统计学意义(P均<0.01)。直线相关性分析结果显示,高血压并下肢动脉硬化组血清hs-CRP与bigET-1(r=0.876,P<0.01)、尿酸与bigET-1(r=0.569,P<0.01)及hs-CRP与尿酸(r=0.439,P<0.01)均呈正相关关系。Logistic回归分析显示,hs-CRP、bigET-1为高血压病并下肢动脉硬化患者的独立危险因素(P均<0.01)。结论 hs-CRP、bigET-1及尿酸水平的升高,是预测老年高血压发生外周血管病变危险较敏感的指标,hs-CRP、bigET-1为独立危险因素。
Objective To investigate the relationship between the changes of serum high-sensitivity C-reactive protein (hs-CRP), bigET-1 and uric acid in elderly patients with essential hypertension and lower extremity arteriosclerosis. Methods Thirty-five elderly patients with essential hypertension, hypertension and lower extremity arteriosclerosis and control group were respectively enrolled in this study. Serum levels of hs-CRP, bigET-1 and uric acid in each group were measured and the results were statistically analyzed. Results The levels of hs-CRP, bigET-1 and uric acid in hypertension and lower extremity atherosclerosis were significantly higher than those in patients with hypertension and control group (all P <0.01). The linear correlation analysis showed that there was significant difference between hs-CRP and bigET-1 (r = 0.876, P <0.01), uric acid and bigET-1 And uric acid (r = 0.439, P <0.01) showed a positive correlation. Logistic regression analysis showed that hs-CRP and bigET-1 were independent risk factors of hypertension and lower extremity arteriosclerosis (all P <0.01). Conclusions The increase of hs-CRP, bigET-1 and uric acid levels is a sensitive index to predict the risk of peripheral vascular disease in senile hypertension. The hs-CRP and big ET-1 are independent risk factors.