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目的一氧化氮 (NO)是内皮细胞分泌的扩血管因子 ,测定NO代谢产物及NO合成酶的浓度可反映内生性NO的变化。 方法分别于手术前、体外循环降温结束、升温开始和停体外循环时测定两者的浓度。 结果术前NO代谢产物及NO合成酶的浓度分别为 5 0 .2± 1 0 .6 μmol/L和 34 .5± 8.9μmol/L ,降温结束时 ,两者浓度均显著降低。此后略有升高 ,升温以后都显著增加 ,分别达 6 0 .8± 2 0 .4μmol/L和45 .3± 1 3.2 μmol/L。 结论本实验显示 ,体外循环中内生性NO升高 ,特别在升温阶段升高明显。这同升温阶段炎症反应加剧 ,炎症因子浓度增高有关
Aim Nitric oxide (NO) is a vasodilator factor secreted by endothelial cells. The determination of NO metabolites and NO synthase concentrations can reflect endogenous NO changes. Methods Preoperative and extracorporeal circulation cooling ended, the temperature began to start and stop the body when the concentration of both outside the cycle. Results The preoperative NO metabolites and NO synthase concentrations were 50.2 ± 1.06 μmol / L and 34.5 ± 8.9 μmol / L, respectively. At the end of cooling, the concentrations of both NO and NO synthase were significantly decreased. After a slight increase, there was a significant increase after heating up to 60.8 ± 20.4μmol / L and 45.3 ± 1.3.2 μmol / L, respectively. Conclusion This experiment shows that endogenous NO increases during cardiopulmonary bypass, especially during the warming phase. This warming phase with increased inflammatory response, increased concentrations of inflammatory cytokines