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目的：了解脑肿瘤细胞增殖活性、纤维连接蛋白表达及脑瘤微血管病变的相互关系及意义。方法：免疫组化观察ＰＣＮＡ标记率，ＦＮ表达情况，电镜观察脑肿瘤微血管病变。结果：ＰＣＮＡ在髓母细胞瘤标记率最高，其次为胶质瘤Ⅳ、Ⅲ级，恶性脑膜瘤，Ⅰ、Ⅱ级标记率低，良性脑膜瘤为０。ＦＮ在各肿瘤表达不一。胶质瘤微血管超微结构改变明显。结论：肿瘤细胞增殖活性（ＰＣＮＡ）与ＦＮ表达，微血管病变同步相关，能反应肿瘤细胞分化、组织学分级和良恶性。
OBJECTIVE: To investigate the relationship between the proliferation activity of brain tumor cells, the expression of fibronectin and brain tumor microangiopathy. Methods: Immunohistochemistry was used to observe the labeling rate of PCNA and the expression of FN, and electron microscopy was used to observe the brain tumor microangiopathy. Results: The highest labeling rate of PCNA was in medulloblastoma, followed by grade Ⅳ and grade Ⅲ malignant meningiomas. The labeling rates of grade Ⅰ and Ⅱ were low, and benign meningioma was 0. FN varies in each tumor. Glioma microvascular ultrastructure changes significantly. Conclusion: The proliferative activity of tumor cells (PCNA) correlates with the expression of FN and microvessel lesion synchronously, which can reflect tumor cell differentiation, histological grade and benign and malignant tumors.