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目的研究中枢神经系统感染患儿脑脊液中神经元特异性烯醇化酶(NSE)和β2-微球蛋白(β2-MG)的变化及临床意义。方法采用电化学发光法检测NSE的水平,应用速率散射比浊法(LAT)测β2-MG水平。结果化脓性脑膜炎组急性期NSE和β2-MG水平分别为(15.7±4.2)μg/L和(8.1±2.4)mg/L,结核性脑膜炎组急性期两项指标分别为(18.4±6.5)μg/L和(12.6±5.0)mg/L,病毒性脑膜炎组急性期两项指标分别为(10.8±3.7)μg/L和(4.3±2.4)mg/L;化脓性脑膜炎组、结核性脑膜炎组和病毒性脑膜炎组的急性期两项检测指标显著高于其恢复期和对照组水平,差异有统计学意义(P<0.01);化脓性脑膜炎组、结核性脑膜炎组急性期NSE和β2-MG水平显著高于病毒性脑膜炎组急性期的水平,差异有统计学意义(P<0.01);急性期β2-MG水平结核性脑膜炎组显著高于化脓性脑膜炎组,差异有统计学意义(P<0.01)。结论脑脊液NSE和β2-MG的检测对中枢神经系统感染患儿具有一定的辅助鉴别价值。
Objective To study the changes and clinical significance of cerebrospinal fluid neuron-specific enolase (NSE) and β2-microglobulin (β2-MG) in children with central nervous system infection. Methods The level of NSE was detected by electrochemiluminescence method. The level of β2-MG was measured by rate nephelometry (LAT). Results The levels of NSE and β2-MG in acute purulent meningitis group were (15.7 ± 4.2) μg / L and (8.1 ± 2.4) mg / L, respectively. The two indicators in acute meningitis group were (18.4 ± 6.5) ) and (12.6 ± 5.0) mg / L respectively in the viral meningitis group (10.8 ± 3.7 μg / L and 4.3 ± 2.4 mg / L, respectively) The two indexes in acute stage of tuberculous meningitis and viral meningitis were significantly higher than those in convalescent stage and control group (P <0.01); purulent meningitis group, tuberculous meningitis The levels of NSE and β2-MG in the acute stage were significantly higher than those in the acute stage of viral meningitis (P <0.01). The levels of β2-MG in the acute stage were significantly higher than those in the purulent meningitis Yan group, the difference was statistically significant (P <0.01). Conclusion The detection of cerebrospinal fluid NSE and β2-MG has some auxiliary value in children with CNS infection.