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1 对实验性关节炎的治疗作用白细胞介素1受体拮抗剂(Ｉｎｔｅｒｌｅｕｋｉｎ1ｒｅｃｅｐｔｏｒａｎｔａｇｏｎｉｓｔ,ＩＬ1ｒａ)可显著影响体内和体外关节炎模型的过程和最终结果。由人单核细胞产生的ＩＬ1ｒａ,已证实可以抑制软骨细胞和滑膜细胞产生前列腺素,并抑制ＩＬ1激活
1 Therapeutic Effects on Experimental Arthritis Interleukin 1 receptor antagonist (IL1ra) significantly affects the course and end result of in vivo and in vitro arthritis models. IL1ra produced by human monocytes has been shown to inhibit the production of prostaglandins by chondrocytes and synoviocytes and inhibit IL1 activation