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目的考察孕妇血清、脐血及胎盘组织中髓过氧化物酶(MPO)水平和子痫前期发病关系。方法收集2010年5月-2013年10月在该院产科住院分娩并确诊的76例重度子痫前期孕妇,按发病时孕周是否大于34周分为早发型子痫前期组(<34周,35例)和晚发型子痫前期组(>34周,41例);另选取同期正常晚期妊娠孕妇62例为对照,分为对照组1(30例)和对照组2(32例)。结果对照组血清MPO水平相当,与对照组比,子痫前期组血清MPO水平显著增高,与晚发子痫前期组比,早发子痫前期组的血清MPO水平显著增高,差异有统计学意义(P<0.05);与对照组2比,子痫前期组的脐血MPO水平较高,差异有统计学意义(P<0.01)。与晚发子痫前期组比,早发子痫前期的脐血MPO水平较高,差异有统计学意义(P<0.01)。与对照组1比,对照组2胎盘组织MPO水平较高,差异有统计学意义(P<0.01)。与对照组2比,子痫前期组胎盘组织的MPO水平较高,差异有统计学意义(P<0.01)。与对照组比,子痫前期组的MPO水平显著增高,与晚发子痫前期比,早发胎盘组织的MPO水平显著增高,差异有统计学意义(P<0.01)。结论 MPO可能通过氧化应激参与子痫前期的发病。
Objective To investigate the relationship between the levels of myeloperoxidase (MPO) in maternal serum, umbilical cord blood and placenta and the incidence of preeclampsia. Methods Seventy-six pregnant women with severe preeclampsia who were hospitalized in obstetrics and gynecology department from May 2010 to October 2013 were divided into preeclampsia group (<34 weeks, 35 cases) and late-onset preeclampsia group (> 34 weeks, 41 cases). Another 62 pregnant women with normal late pregnancy as control were divided into control group (n = 30) and control group (n = 32). Results Compared with control group, serum MPO level in control group was significantly higher than that in control group, and serum MPO level in preeclampsia group was significantly higher than that in late onset preeclampsia group, and the difference was statistically significant (P <0.05). Compared with the control group 2, MPO levels in umbilical cord blood of preeclampsia group were higher (P <0.01). Compared with late-onset preeclampsia group, pre-eclampsia pre-eclamptic MPO levels were higher, the difference was statistically significant (P <0.01). Compared with control group 1, the level of MPO in control group 2 placenta was higher, the difference was statistically significant (P <0.01). Compared with control group 2, the level of MPO in placenta of preeclampsia group was higher, the difference was statistically significant (P <0.01). Compared with the control group, the MPO level in preeclampsia group was significantly higher than that in the preeclampsia group (P <0.01). Conclusion MPO may be involved in the pathogenesis of preeclampsia through oxidative stress.