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近十余年来,不同种类的半合成抗生素不断涌现并应用于临床上。β-内酰胺类最令人瞩目,其中头孢菌素类的品种尤多。但以产量和应用广泛程度而言,则半合成头孢菌素类远不如半合成青霉素类。非典型β-内酰胺类有单环β-内酰胺类(Monobactams)、碳青霉烯类(Carbapenems)、氧头孢烯类(Oxacephems)、氧青霉烷类(Oxapenems)和青霉烷砜类(Penicillanic acid Sulfones)等,其主要代表分别为氨噻羧单胺菌素(Aztreonam),亚胺硫霉素(Imipenem)、羟羧氧酰胺菌素(Moxalactam)、棒酸(Clavulanic acid)和青霉烷砜(Sulbactam)等。
In the recent ten years, different types of semi-synthetic antibiotics continue to emerge and apply to the clinic. β-lactams most eye-catching, of which more cephalosporins varieties. However, in terms of yield and wide range of applications, the semisynthetic cephalosporins are far less semisynthetic penicillins. Atypical β-lactam Monobactams, Carbapenems, Oxacephems, Oxapenems and Penicillins Sulfones (Penicillanic acid Sulfones) and so on, the main representatives were respectively Aminothiazocine amine (Aztreonam), Imipenem (Imipenem), hydroxycarboxamycin (Moxalactam), clavulanic acid (Clavulanic acid) Sulbactam and the like.