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目的:探讨同一个体食管贲门双原发癌组织中Survivin和E-cadherin蛋白变化特征及其意义。方法:采用组织病理学方法和免疫组化ABC法,分析15例食管贲门双原发癌患者食管鳞癌(SCC)和贲门腺癌(GCA)组织Survivin和E-cadherin蛋白的表达状况。结果:15例食管贲门双原发癌患者SCC和GCA组织均出现不同程度的Survivin蛋白的阳性表达和E-cadherin蛋白的异常表达,Survivin在SCC组织中免疫阳性率为71%(10/14),在GCA组织中为33%(5/15);E-cadherin在SCC组织中免疫异常表达率为93%(13/14),在GCA组织中为93%(14/15)。Survivin蛋白在食管贲门双原发癌SCC和GCA组织中一致性表达率为58%(8/14);E-cadherin蛋白一致性表达率为86%(12/14)。结论:食管癌和贲门癌可能具有相似的发病因素和分子机制。
Objective: To investigate the characteristics and significance of survivin and E-cadherin protein in the double primary cancer tissues of esophagus and cardia of the same individual. Methods: The expression of survivin and E-cadherin protein in esophageal squamous cell carcinoma (SCC) and cardia adenocarcinoma (GCA) tissues were analyzed by histopathological method and immunohistochemical ABC method. Results: The positive expression of Survivin protein and the abnormal expression of E-cadherin protein were found in 15 cases of SCC and GCA tissues. The positive rate of Survivin in SCC tissues was 71% (10/14). , 33% (5/15) in GCA tissue; E-cadherin immunostaining rate in SCC tissue was 93% (13/14), and 93% (14/15) in GCA tissue. The Survivin protein was expressed in 58% (8/14) of the esophageal cardia-double primary cancer SCC and GCA tissues, and the E-cadherin protein coexpression rate was 86% (12/14). Conclusion: Esophageal and cardiac cancers may have similar pathogenesis and molecular mechanisms.