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[目的]了解哈尔滨地区孕妇血液中有机物成分及邻苯二甲酸酯类暴露水平。[方法]随机选取哈尔滨市区和郊区健康的孕妇100名,分别采集全血2 mL,并收集调查问卷表,应用气相色谱-质谱联用技术对血液中有机物成分进行定性分析,并对邻苯二甲酸酯做定量分析。[结果]孕妇全血样品中共检出有机物70种,其中邻苯二甲酸酯类4种,分别为邻苯二甲酸丁酯(DBP)、邻苯二甲酸(2-乙基)己酯(DEHP)、邻苯二甲酸二异丁酯(DIBP)、邻苯二甲酸二甲酯(DMP)。市区与郊区、20岁~、30岁~组孕妇血液中4种邻苯二甲酸酯含量差异均无统计学意义。常用塑料制品打包或加热食物组孕妇血液中DBP、DIBP含量明显高于不使用组(DBP,P=0.041;DIBP,P=0.004)。[结论]哈尔滨市孕妇全血中检出多种环境有机污染物,使用塑料制品盛装或加热食物可导致孕妇血液中邻苯二甲酸酯类暴露。
[Objective] To understand the blood composition of organic matter and phthalate exposure in pregnant women in Harbin. [Methods] A total of 100 healthy pregnant women in urban and suburban areas of Harbin were randomly selected, and 2 mL of whole blood was collected. The questionnaires were collected and analyzed by gas chromatography-mass spectrometry (GC-MS) Dicarboxylic acid esters for quantitative analysis. [Result] Seventy kinds of organic compounds were detected in the whole blood samples of pregnant women, including 4 kinds of phthalates, such as dibutyl phthalate (DBP), 2-ethylhexyl phthalate (DEHP ), Diisobutyl phthalate (DIBP), dimethyl phthalate (DMP). There was no significant difference in the contents of 4 phthalates in the blood of pregnant women between the age of 20 ~ 30 in the urban and suburban areas. The levels of DBP and DIBP in the blood of pregnant women packaged or heated with common plastic products were significantly higher than those of non-used groups (DBP, P = 0.041; DIBP, P = 0.004). [Conclusion] A variety of environmental organic pollutants were detected in whole blood of pregnant women in Harbin. The use of plastic products to dress or heat food can cause phthalates in the blood of pregnant women to be exposed.