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心脏毒性是阿霉素治疗的常见并发症。115例儿童曾用阿霉素治疗急性淋巴细胞性白血病而且病情一直缓解,评价该药对心脏的远期影响。 115例患儿中男58例,女57例;心脏受检时年龄中位数为13.6(3.9～31.7)岁。18例接受阿霉素一次,剂量45mg/m~2。97例接受多次剂量,总量中位数为360(228～550)mg/m~2。治疗结束至心脏受检的时间中位数为6.4(1～15)年。了解病史并作24小时动态心电图、运动试验和超声心动图。
Cardiotoxicity is a common complication of doxorubicin treatment. 115 children with adriamycin have been treated with acute lymphoblastic leukemia and the disease has been alleviated, the drug’s evaluation of the long-term impact on the heart. Among 115 children, 58 were male and 57 were female. The median age at heart examination was 13.6 (3.9-31.7) years. Eighteen of the 18 patients received doxorubicin at a dose of 45 mg / m ~ 2.97 for multiple doses, with a median total of 360 (228-550) mg / m ~ 2. The median time to treatment for cardiac arrest was 6.4 (1-15) years. Understand the history and make 24-hour Holter, exercise test and echocardiography.