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以3-巯基丙酸为稳定剂,采用水相合成法合成Mn掺杂的ZnS量子点,该量子点在室温条件下能够发射较强的磷光信号。十六烷基三甲基溴化铵(CTAB)作为一种阳离子表面活性剂能够与该量子点发生静电作用,最终与量子点聚合形成Mn掺杂的ZnS量子点/CTAB纳米复合材料,使量子点的室温磷光(RTP)强度明显增强。加入米托蒽醌(MXT)后,MXT能够与CTAB通过疏水作用和结构作用结合成为更加稳定的混合物,最终导致CTAB从量子点的表面脱离,进而使该量子点的室温磷光强度降低。结果表明该纳米复合材料能够大大提高量子点对MXT的检测性能,可由此建立高效、灵敏的检测MXT的室温磷光传感器。在最优条件下,该传感器对MXT的检出限为0.23nmol/L,线性范围为0~200nmol/L,相关系数R为0.99,且尿液和血清实际样品的检测回收率为98.6%~102.5%。该量子点磷光分析方法简便快速、灵敏度高、选择性好,能够用于体液中MXT含量的分析与检测。
Mn-doped ZnS quantum dots were synthesized by aqueous phase synthesis using 3-mercaptopropionic acid as a stabilizer. The quantum dots can emit strong phosphorescent signals at room temperature. As a cationic surfactant, cetyltrimethylammonium bromide (CTAB) can electrostatically interact with the quantum dots and eventually polymerizes with the quantum dots to form Mn-doped ZnS QDs / CTAB nanocomposites, allowing quantum dots Point of the room temperature phosphorescence (RTP) intensity was significantly enhanced. With the addition of mitoxantrone (MXT), MXT can combine with CTAB to form a more stable mixture through hydrophobic interaction and structural interaction, which eventually leads to the detachment of CTAB from the surface of the quantum dot, thereby reducing the room-temperature phosphorescence intensity of the quantum dot. The results show that the nanocomposites can greatly improve the detection performance of the quantum dots on the MXT, thereby establishing an efficient and sensitive room temperature phosphorescence sensor for detecting MXT. Under optimal conditions, the detection limit of MXT for this sensor was 0.23nmol / L, the linear range was 0 ~ 200nmol / L, the correlation coefficient R was 0.99, and the detection recoveries of real samples of urine and serum were 98.6% 102.5%. The quantum dot phosphorescence method is simple and fast, has high sensitivity and good selectivity, and can be used for the analysis and detection of MXT content in body fluids.