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探讨急性髓系白血病(AML)一疗程缓解与一疗程内死亡患者白血病细胞的形态定量参数的差异及临床意义。方法:用体视学方法,利用普通光镜,手工测试23例 AML 患者首次骨髓瑞化染色涂片中白血病细胞各自参数,并进行形态定量分析。结果:AML、M_1、M_2型缓解组胞体参数明显大于死亡组(P<0.01),M_3、M_4型缓解组胞体参数小于死亡组(P<0.05)。胞核参数缓解组均大于死亡组(部分 P<0.01)。结论:测量 AML 细胞形态学参数可能较早期地提示患者的预后。
To investigate the difference of morphometric quantitative parameters of leukemia cells in acute myeloid leukemia (AML) between one course of remission and death in one course of treatment and its clinical significance. Methods: Using stereological methods, using ordinary light microscope, hand-tested the parameters of leukemic cells in the first myeloid stained smears of 23 patients with AML, and performed morphometric quantitative analysis. Results: The cell parameters of the remission group AML, M_1, and M_2 were significantly higher than those of the death group (P<0.01). The cell parameters of the M_3 and M_4 remission groups were lower than the death group (P<0.05). The nuclear parameter remission group was greater than the death group (partial P<0.01). CONCLUSIONS: Measurement of morphological parameters in AML cells may indicate the patient’s prognosis earlier.