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目的:比较埃索美拉唑、阿莫西林、克拉霉素、替硝唑组成的10日序贯疗法与标准三联疗法根除幽门螺杆菌(Hpylori)的疗效.方法:将我院经胃镜检查确诊为慢性胃炎和消化性溃疡且Hpylori阳性的患者79例随机分为2组,治疗组(39例)方案:前5d,埃索美拉唑20mg+阿莫西林1000mg,每日2次;后5d,埃索美拉唑20mg+克拉霉素500mg+替硝唑500mg,每日2次.对照组(40例)标准三联疗法:埃索美拉唑20mg+克拉霉素500mg+阿莫西林1000mg,每日2次,疗程7d.所有患者停药4wk后复查13C呼气试验,判断Hpylori根除率.结果:治疗组Hpylori根除率为94.87%,对照组77.50%,2组比较差异具有统计学意义(χ2=4.97,P<0.05),且序贯疗法并未增加患者的经济负担.2种方案不良方应的发生率无明显差异(χ2=0.05,P>0.05).结论:10日序贯疗法治疗Hpylori感染明显优于7日标准三联疗法,是一种安全、经济、有效的方案选择.
Objective: To compare the efficacy of 10-day sequential therapy and standard triple therapy of esomeprazole, amoxicillin, clarithromycin and tinidazole in the eradication of Hpylori.Methods: The hospital was diagnosed by gastroscopy 79 patients with chronic gastritis and peptic ulcer and Hpylori positive were randomly divided into two groups. The treatment group (39 cases) was given 5 days before esomeprazole 20 mg and amoxicillin 1000 mg twice daily, Esomeprazole 20mg + clarithromycin 500mg + tinidazole 500mg, twice a day.Control group (40 cases) standard triple therapy: esomeprazole 20mg + clarithromycin 500mg + amoxicillin 1000mg, 2 times a day, Treatment 7d.All patients were withdrawn after 4wk 13C breath test to determine the Hpylori eradication rate.Results: The treatment group Hpylori eradication rate was 94.87%, 77.50% in the control group, the difference between the two groups was statistically significant (χ2 = 4.97, P <0.05), and sequential therapy did not increase the economic burden of patients.No significant difference in the incidence of adverse side of the two programs (χ2 = 0.05, P> 0.05) .Conclusion: 10 sequential treatment of Hpylori infection was significantly better On the 7th standard triple therapy, is a safe, economical and effective program options.