论文部分内容阅读
观察利多卡因对肠缺血再灌注 (I/R)所致急性肺损伤 (ALI)的保护作用。成年SD大鼠随机分为 4组 (n =8) :对照组 ,只分离而不阻断肠系膜上动脉 ;I/R组 ,肠I/R(6 0 / 180min) ;利多卡因组 (2组 ) ,分别于再灌注即刻或再灌注 6 0min后静脉给利多卡因 2mg/kg。利多卡因再灌注即刻用药组MAP下降 ,肺通透性、血中TNF α水平及肺组织TNF αmRNA表达增高 ,与I/R组比较差异显著 (P <0 .0 5 ) ,肺组织病理损害亦明显减轻 ;再灌注 6 0min用药对MAP、血中TNF α水平无明显影响 (P >0 .0 5 ) ,病理损害也无明显改善。结果提示 ,预防性应用利多卡因可减轻肠I/R后肺损伤 ,可能与其减少PMN肺内聚集以及抑制TNF α合成有关
To observe the protective effect of lidocaine on acute lung injury induced by intestinal ischemia / reperfusion (I / R). Adult SD rats were randomly divided into 4 groups (n = 8): the control group, only the superior mesenteric artery was isolated without blocking; the I / R group, the intestinal I / R Group) were given intravenous lidocaine 2mg / kg immediately after reperfusion or 60min after reperfusion. MAP decreased, pulmonary permeability, blood TNFα mRNA level and TNFαmRNA expression in lung tissue increased immediately after reperfusion of lidocaine, compared with I / R group (P <0.05), pathological damage of lung tissue Also significantly reduced; reperfusion 60min medication on the MAP, blood TNFα levels had no significant effect (P> 0.05), pathological lesions also did not improve significantly. The results suggest that prophylactic use of lidocaine may reduce lung injury following intestinal I / R, which may be related to its reduction of PMN accumulation in the lung and inhibition of TNFα synthesis