论文部分内容阅读
目的探讨有病理性说谎的反社会人格障碍(APD)患者,在执行说谎任务时脑区激活模式及对揭示疾病功能机制的重要意义。方法对20例有欺骗行为的APD患者(APD说谎组)、20例无欺骗行为的患者(APD对照组)和20例正常人(正常对照组),应用磁共振进行任务状态下的功能像扫描。使用SPM2软件分析3组受试在不同条件下脑区激活的差异。结果在说谎任务中,APD说谎组对比APD对照组激活增加的脑区有:左楔前叶(BA19)、左颞叶(BA37、39)、左额叶(BA6、46)、左扣带回(BA24)、右枕叶及右小脑。APD对照组与正常对照组比较无激活显著增加的脑区。结论有说谎行为的APD人群,在说谎时有其特有的脑部激活模式,可能是其习惯性说谎行为的神经联系基础。
Objective To explore the pattern of brain activation in patients with pathologically lying antisocial personality disorder (APD) and the importance of revealing the functional mechanisms of disease in performing lying tasks. Methods Twenty patients with degenerative APD (APD lie group), 20 patients without deception (APD control group) and 20 healthy controls (normal control group) were enrolled in this study. MRI scan of functional status . The SPM2 software was used to analyze differences in brain activation in three groups under different conditions. Results In the Lying Quest, the increased brain areas in the APD control group compared with those in the APD control group were left anterior lobe (BA19), left temporal lobe (BA37, 39), left frontal lobe (BA6, 46) (BA24), right occipital and right cerebellum. APD control group compared with the normal control group no significant increase in brain area. Conclusions There is a peculiar pattern of brain activation when lying because of the lying behavior of APD people, which may be the neural connection basis of habitual lying behavior.