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目的:研究海洛因依赖小白鼠的生育情况。方法:先腹腔注射海洛因,6天后腹腔注射盐酸纳洛酮进行催促实验,海洛因依赖模型建立后,分成二组:一组继续注射海洛因,一组停止注射海洛因,在d14,将已对海洛因产生依赖的♀♂小白鼠各10只,作为海洛因依赖组;已脱毒的♀♂小白鼠各10只,作为海洛因戒断组;已对海洛因产生依赖的♀小白鼠10只与NS组的♂小白鼠10只,作为海洛因♀依赖组;已对海洛因产生依赖的♂小白鼠10只与NS组的♀小白鼠10只,作为海洛因♂依赖组;剩余的NS对照组♀♂小白鼠各10只,作为NS对照组。各组♀♂分别配对,观察不同组别小白鼠生育情况。结果:海洛因依赖组、海洛因戒断组、海洛因♂依赖组、海洛因♀依赖组与NS对照组比较,有极显著差异(P<0.001),海洛因依赖组与海洛因戒断组比较有显著性差异(P<0.05),海洛因♂依赖组与海洛因♀依赖组比较,无显著性差异(P>0.05)。结论:海洛因对♀♂小白鼠的生育能力均有明显影响。
Objective: To study the fertility of heroin dependent mice. Methods: Six days later, intraperitoneal injection of naloxone hydrochloride was used to induce the experiment. After the heroin dependence model was established, the heroin dependence model was divided into two groups: one group continued to inject heroin and the other group stopped heroin injection. On d14, heroin dependence Of ♀♂ mice each 10, as a heroin dependence group; detoxified ♀♂ mice each 10, as heroin abstinence group; has been dependent on heroin 10 ♀ mice and NS group ♂ mice 10 as heroin dependence group; 10 heroin-dependent white mice and 10 white rats of NS group as heroin dependent group; and the remaining NS control group, 10 male mice each, as the NS control group. Each group ♀ ♂ paired to observe the different groups of mice reproductive situation. Results: There were significant differences (P <0.001) between heroin dependence group, heroin addicts group, heroin dependence group and heroin addicts group (P <0.001), heroin dependence group and heroin abstinence group P <0.05). There was no significant difference between heroin addicts and heroin addicts (P> 0.05). Conclusion: Heroin has significant effects on the fertility of ♀♂ mice.