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成人呼吸窘迫综合征(ARDS)以肺动脉高压和静脉血右至左分流为特征。作者调查了吸入一氧化氮(NO)是否会选择性地扩张通气肺区血管,由此导致肺动脉高压下降并改善气体交换。 方法 10例ARDS患者中9例吸入两种浓度(18ppm,36ppm)的NO共40分钟。用复合的无效气体排出技术对血液流变学、气体交换和通气-灌注分布进行测量,其结果与静滴前列环素所获得的上述数据比较。7例患者每天吸入5～20ppm的NO30分钟计3～53天。
Adult respiratory distress syndrome (ARDS) is characterized by pulmonary hypertension and venous blood flow from right to left. The authors investigated whether inhaled nitric oxide (NO) selectively expands the pulmonary veins in the ventilatory area, leading to a decrease in pulmonary hypertension and improved gas exchange. Methods Nine of 10 ARDS patients inhaled NO at both concentrations (18 ppm, 36 ppm) for 40 minutes. Hemorheology, gas exchange, and ventilation-perfusion distribution were measured using composite ineffective gas discharge techniques and the results were compared with those obtained with intravenous prostacyclin. Seven patients inhaled 5 ~ 20ppm NO30 minutes a day for 3 to 53 days.