论文部分内容阅读
目的研究采用阿托伐他汀治疗高脂血症伴脑梗死,对患者的血脂、颈动脉粥样硬化的影响。方法选择2013年12月—2014年12月治疗高脂血症伴脑梗死的患者108例,随机将其分成对照组和治疗组,每组各54例。对照组采用常规对症治疗,治疗组采用常规对症治疗+阿托伐他汀共同治疗。观察两组患者治疗前及治疗后3、6、12个月血脂、颈动脉粥样硬化情况。结果治疗后6、12个月,治疗组的血脂水平、颈动脉IMT与治疗前相比,差异均有统计学意义(P<0.05),治疗组颈动脉IMT与对照组相比,差异有统计学意义(P<0.05);治疗后12个月,治疗组的血脂水平与对照组相比,差异有统计学意义(P<0.05)。结论对高脂血症伴脑梗死的患者采用阿托伐他汀治疗效果明显,能有效的降低TC、LDL-C水平,同时对改善动脉粥样硬化也有明显效果,可推广应用。
Objective To study the effects of atorvastatin on lipids and carotid atherosclerosis in patients with hyperlipidemia and cerebral infarction. Methods A total of 108 patients with hyperlipidemia and cerebral infarction from December 2013 to December 2014 were randomly divided into control group and treatment group, 54 cases in each group. The control group was treated with conventional symptomatic treatment, and the treatment group was treated with conventional symptomatic treatment plus atorvastatin. The levels of lipids and carotid atherosclerosis in two groups before and after treatment were observed at 3, 6 and 12 months after treatment. Results At 6 and 12 months after treatment, the levels of blood lipids and carotid IMT in the treatment group were significantly different from those before treatment (P <0.05). There was statistical difference between the IMT in the treatment group and the control group (P <0.05). At 12 months after treatment, the blood lipid level in the treatment group was significantly different from that in the control group (P <0.05). Conclusions Atorvastatin is effective in patients with hyperlipidemia and cerebral infarction. It can effectively reduce the level of TC and LDL-C, and also has obvious effect on improving atherosclerosis and can be applied widely.