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目的观察胰岛素样生长因子-I(IGF-I)及其受体(IGF-IR)在子宫腺肌症患者原位及异位内膜表达,以探讨子宫腺肌症发生维持及侵袭的机制。方法取20例子宫腺肌症患者的原位和异位内膜标本作为病例组,另取22例正常内膜作为对照组。采用免疫组织化学方法检测IGF-I,IGF-IR的分布及表达。结果正常内膜及子宫腺肌症的原位和异位内膜组织中均有IGF-I,IGF-IR的表达,IGF-I在异位内膜组织中表达较高(P<0.05=。结论IGF-I可能参与子宫腺肌症的异位内膜生长与维持。
Objective To investigate the expression of insulin-like growth factor-I (IGF-I) and its receptor (IGF-IR) in eutopic and ectopic endometrium of patients with adenomyosis in order to investigate the mechanism of the maintenance and invasion of adenomyosis. Methods Twenty eutopic and ectopic endometrial specimens from patients with adenomyosis were selected as the case group and 22 normal endometrium as the control group. Immunohistochemistry was used to detect the distribution and expression of IGF-I and IGF-IR. Results The expression of IGF-I and IGF-IR both in situ and in ectopic endometrium of normal endometrium and adenomyosis, and the expression of IGF-I in ectopic endometrium were higher (P <0.05). Conclusion IGF-I may be involved in ectopic endometrial growth and maintenance of adenomyosis.