Objective The purpose of this study w as to evaluate the angiotensin -converting enzyme gen e polymorphism in pregnant women with and without pree clampsia.Study de-sign Preeclampsia was defined as hyp ertension and patho-logic proteinuria in pregnantwomen after gestationalweek20.Genomic DNA was isolated from leu kocytes.The in-sertion -deletion polymorphism in i ntron 16of the an-giotensin -converting enzyme gene w as detected in DNA samples with the use of the polymerase chain reaction.Chi -squared and Student t tests were used for statisticalanalysis.Results In preeclampsia(n =51women)an-giotensin -converting enzyme genotypes were deletion -D(DD)in 16women(31%),insertion -I (II)in 12women(24%),and insertion -deletion in 23women(45%);in the control group(n =71),the angiotensin -converting enzyme genotypeswere DDin 21women(30%),II in 17women(24%),and insertion -deletion in 33women(46%).Angiotensin -converting enzyme genotype distri-bution and allelic frequencies were not different between groups.Conclusion No difference in the angiotensin -converting enzyme genotype distrib utionwas found between preeclampsia and normal pregnancy.The results showed no association between angiotensin -c onverting enzyme poly-morphism and the development of preeclampsia. Objective The purpose of this study w as to evaluate the angiotensin -converting enzyme gen e polymorphism in pregnant women with and without pree clampsia. Stuy de-sign Preeclampsia was defined as hyp ertension and patho-logic proteinuria in pregnantwomen after gestational week 20. Genomic DNA was isolated from leu kocytes. The in-sertion -deletion polymorphism in itron 16 of the an-giotensin -converting enzyme gene w as detected in DNA samples with the use of the polymerase chain reaction. Chi-squared and Student t tests were used for statisticalanalysis . Results In preeclampsia (n = 51 women) an-giotensin -converting enzyme genotypes were deleted-D (DD) in 16 women (31%), insertion- 45%); in the control group (n = 71), the angiotensin -converting enzyme genotypeswere DDin 21 women (30%), II in 17 women (24%), and insertion -detetion in 33 women genotype distri-bution and allelic frequencies were not different bet ween groups. Confluence No difference in the angiotensin -converting enzyme genotype distrib utionwas found between preeclampsia and normal pregnancy. result results no association between angiotensin-c onverting enzyme poly-morphism and the development of preeclampsia.