论文部分内容阅读
Ｅ８３８是一种新型放射防护剂，为炔雌醇衍生物。小鼠照射８Ｇｙ前第３、２、１天连续口服或腹腔注射Ｅ８３８０．２５μｇ／０．２ｍｌ，结果显示Ｅ８３８对受照小鼠ＣＦＵ－Ｓ（脾集落生成单位）和ＢＭＮ（骨髓有核细胞数）有明显的保护作用（经统计学处理差异有显著性）。为临床应用Ｅ８３８治疗放疗、化疗患者的白细胞减少症提供了依据
E838 is a new type of radioprotective agent that is a derivative of ethinylestradiol. The mice were irradiated with E8380.25μg/0.2ml on the 3rd, 2nd day before or after 8Gy irradiation. The results showed that E838 treated CFU-S (spleen colony-forming units) and BMN (bone marrow nucleated cells) in the irradiated mice. ) There is a clear protective effect (significance is statistically significant). Provides basis for the clinical application of E838 in the treatment of leukopenia in patients undergoing radiotherapy and chemotherapy