论文部分内容阅读
目的 通过对2型糖尿病（DM）患者进行刺激正中神经（MN）和胫后神经（PTN）诱发的体感诱发电位（SEP）的检查,了解病人躯体深感觉通路功能状态,早期发现病人的神经病变。方法 用Nicolet Viking TV型肌电图/诱发电位仪对30例2型DM患者进行SEP的检测并与正常人对照。应用SPSS统计软件采用t检验、卡方检验及多元逐步回归分析比较两组间SEP各项参数的差异,分析DM组SEP参数变化与血糖、血脂、肾功能之间的关系。结果①DM组MNSEP异常20例（66.7％）,PTNSEP异常22例（73.3％）,表现为波形缺失、波潜伏期延长及波幅下降。②DM组MNSEP的N9～N20潜伏期、波幅异常（P<0.05）;PTNSEP的N9～P38潜伏期、波幅异常（P<0.05）。③DM组SEP异常与病程、血糖、血脂、肾功能有关P<0.05）。结论①SEP是检测2型DM神经病变的敏感指标。②控制血糖、血脂、保护肾功能有利于阻止神经病变的发展。
Objective To investigate the functional status of somatosensory deep sensory pathway in patients with type 2 diabetes mellitus (DM) by detecting the somatosensory evoked potential (SEP) induced by the median nerve (MN) and posterior tibial nerve (PTN) . Methods Nicolet Viking TV electromyography / evoked potentials were used to detect SEP in 30 patients with type 2 DM and compared with normal controls. SPSS software was used to compare the differences of SEP parameters between the two groups by t-test, chi-square test and multivariate stepwise regression analysis. The relationship between the changes of SEP parameters and blood glucose, blood lipid and renal function was analyzed. Results ① There were 20 cases (66.7%) of MNSEP abnormalities and 22 cases (73.3%) of PTNSEP abnormalities in DM group, which were as follows: waveform deletion, prolongation of wave latency and decrease of amplitude. ② The N9 ~ N20 latency and amplitude of MNSEP in DM group were abnormal (P <0.05). The latency and amplitude of N9 ~ P38 in PTNSEP were abnormal (P <0.05). ③DM group SEP abnormalities and duration, blood glucose, blood lipids, renal function P <0.05). Conclusions ① SEP is a sensitive index for detecting type 2 DM neuropathy. ② control blood sugar, blood lipids, protect renal function is conducive to stop the development of neuropathy.