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目的 观察羟考酮超前镇痛对气管插管心血管反应和术后疼痛的影响.方法 择期行腹腔镜胆囊切除术患者80例随机分均为两组:麻醉诱导前10 min,试验组静脉输注羟考酮0.3 mg/kg,后以0.2mg·kg1·h-1维持输注至术毕;对照组输注生理盐水作为对照.两组均采用静-吸复合全身麻醉.记录气管插管前(T1)、插管后3 min(T2)、插管后5 min(T3)、拔管前(T4)、拔管后3 min(T5)和拔管后5 min(T6)时的HR和MAP.于术后30 min、1h和2h评估VAS疼痛评分.结果 试验组患者T2、T3、T5和T6时的HR和MAP均低于对照组(P＜0.05).试验组患者术后30 min、1h和2h的VAS疼痛评分均较对照组低(P＜0.05).结论 羟考酮超前镇痛有助于维持腹腔镜胆囊切除术患者气管插管期HR和MAP稳定,并有良好的术后镇痛效果.“,”Objective To observe the effects of preemptive analgesia with oxycodone on circulatory responses to intubation and extubation and postoperative pain.Methods Eighty patients undergoing selective laparoscopic cholecystectomy were randomly divided into two groups with 40 cases each.The patients in group A were treated with preemptive analgesia with oxycodone 0.3 mg/kg iv.at 10 minutes before anesthesia induction,which was followed by infusion of oxycodone 0.2 mg ·kg-1·l-1 until the end of surgery.The patients in group B were infused normal saline as the controls.A combined general anesthesia with intravenous and inhalation drugswas used in both groups.The HR and MAP were recorded before intubation (T1),at 3 minutes (T2) and 5 minutes (T3) after intubation,before extubation(T4),at 3 minutes (T5) and 5 minutes (T6) after extubation.The VAS pain scores were evaluated at 30 minutes,1 hour and 2 hours after operation.Results The HR and MAP at T2,T3,T5 and T6 were significantly lower in group A than those in group B(P＜0.05).The VAS pain scores at 30 minutes,1 hour and 2 hours after operation were less in group A than those in group B(P＜0.05).Conclusion The preemptive analgesia with oxycodone may effectively attenuate the circulatory responses to intubation and extubation and postoperative pain in the patients undergoing laparoscopic cholecystectomy.