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目的观察非诺贝特治疗高三酰甘油(TG)血症的临床效果。方法收集2014年1~12月医院收治的高TG血症患者98例。随机分为对照组与研究组各49例。对照组未予以药物治疗,研究组予非诺贝特治疗。比较2组疗效及不良反应发生率。结果研究组总有效率85.7%明显高于对照组的18.4%,差异有统计学意义(P<0.05)。对照组患者无不良反应发生。研究组丙氨酸转氨酶(ALT)轻度升高1例,未超过正常值2倍。轻度腹胀、恶心2例,不良反应发生率为6.1%,均可耐受,不影响治疗,无退出试验病例。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论非诺贝特可有效降低TG,不良反应小,值得临床推广应用。
Objective To observe the clinical efficacy of fenofibrate in the treatment of hyperglycerilated triglyceride (TG). Methods A total of 98 patients with hypertriglyceridemia admitted to the hospital from January to December 2014 were collected. Randomly divided into control group and study group, 49 cases each. The control group was not treated with drugs, the study group to fenofibrate treatment. The efficacy and adverse reactions of two groups were compared. Results The total effective rate was 85.7% in the study group was significantly higher than that of the control group (18.4%), the difference was statistically significant (P <0.05). Patients in the control group had no adverse reactions. The study group, alanine aminotransferase (ALT) increased slightly in 1 case, did not exceed 2 times the normal value. Mild bloating, nausea in 2 cases, the incidence of adverse reactions was 6.1%, can be tolerated, does not affect the treatment, no exit test cases. The incidence of adverse reactions in the two groups, the difference was not statistically significant (P> 0.05). Conclusion Fenofibrate can effectively reduce the TG, adverse reactions, worthy of clinical application.