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目的 探讨乙型肝炎病毒前 C区基因变异对慢性乙型肝炎患者的影响及前 C区基因变异与 α-干扰素治疗的关系。方法 采用多聚酶链反应银染技术检测 3 2例 HBV DNA阳性慢性乙型肝炎患者用干扰素治疗前后的 HBV前 C区基因变异。结果 在治疗前有前 C区突变株感染 8例 ,突变株检出率为 2 5 % ;在治疗后有前 C区突变株感染 9例 ,突变株检出率为 2 8.1%。HBV DNA阴转 17例 ,阴转率为 5 3 .1%。结论 HBV前 C区基因变异不影响对干扰素的应答
Objective To investigate the influence of pre-C gene mutation of hepatitis B virus on patients with chronic hepatitis B and the relationship between pre-C gene mutation and interferon-α therapy. Methods The gene mutation of pre-HBV precore HBV DNA in 32 patients with HBV DNA-positive chronic hepatitis B before and after treatment with interferon was detected by polymerase chain reaction silver staining. Results Before treatment, there were 8 cases of infection in the former C region, and the detection rate of the mutation was 25%. After treatment, 9 cases were infected by the former C region, and the mutation rate was 21.1%. 17 cases of HBV DNA negative conversion, negative conversion rate of 53.1%. Conclusion Pre-HBV gene mutations do not affect the response to interferon