出生窒息引起的缺氧缺血性脑病(hypoxia/ischemia brain damage,HIBD)常引起不可逆的组织损伤,产生永久性神经功能缺陷,是儿童脑瘫、癫痫及智力低下等神经系统伤残疾病的重要原因。尽管目前临床对HIBD有许多治疗措施,但大多干预其发病的某单一机制,治疗效果不尽理想,特别是对中 Hypoxia / ischemia brain damage (HIBD) caused by birth asphyxia often causes irreversible tissue damage, resulting in permanent neurological deficits and is a major cause of neurological disability diseases such as cerebral palsy, epilepsy and mental retardation in children. . Although there are many clinical treatments for HIBD, most of them interfere with a single mechanism of HIBD. The treatment effect is not satisfactory, especially for moderate