在咨询了加拿大卫生部后,加拿大先灵公司已向医务人员发出劝告:鼓膜穿孔的患者局部使用庆大霉素硫酸盐滴耳液有耳毒性的危险。这一劝告的根据是药物上市后的监测报告中,鼓膜穿孔的患者使用庆大霉素滴耳液后,出现罕见的耳毒性(听力丧失、耳鸣、眩晕、共济失调或振动幻视)。考虑 After consulting Health Canada, Schering Corporation of Canada has advised healthcare providers that there is a risk of ototoxicity of topical gentamicin sulfate ear drops in patients with perforation of the tympanic membrane. This advice is based on a surveillance report after the drug is marketed, with rare ototoxicity (hearing loss, tinnitus, dizziness, ataxia or vibrational hallucinations) in patients who have perforation of the tympanic membrane using gentamicin ear drops. consider