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随着人们饮食结构及生活节奏的改变,急性心肌梗死因其高发病率和高死亡率,已成为当下威胁人类健康的严重心血管疾病,诊断心肌梗死的首要血清标志物也从门冬氨酸氨基转移酶、乳酸脱氢酶等发展为肌酸磷酸激酶同工酶和血清心肌肌钙蛋白Ⅰ(cardiactroponinⅠ,cTnⅠ)。cTnⅠ作为肌肉收缩骨架蛋白存在于细胞内,当心肌发生损伤时,暴露出的隐蔽抗原可刺激免疫系统产生cTnⅠ自身抗体。1996年,
With the changes of people’s diet structure and life rhythm, acute myocardial infarction has become the current serious cardiovascular disease threatening human health due to its high morbidity and mortality. The primary serum markers for diagnosing myocardial infarction also vary from aspartate Aminotransferase, lactate dehydrogenase and other development of creatine phosphokinase isoenzyme and serum cardiac troponin Ⅰ (cardiactroponin Ⅰ, cTn Ⅰ). cTnI acts as a muscle-shrinking scaffolding protein in the cell. When myocardial damage occurs, the exposed antigen can stimulate the immune system to produce cTnI autoantibodies. 1996,