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目的观察藏药三味檀香散对大鼠的长期毒性,为临床安全用药提供依据。方法将大鼠随机分为对照组和高(15 g.kg-1)、中(9 g.kg-1)、低(1.5 g.kg-1)剂量组,日剂量分别为临床成人用量(按0.1 g.kg-1)的150、90、15倍,连续给药90 d,观察大鼠的一般情况、饮食、体重。于实验第45天和第90天,分别剖杀一半大鼠,取血测定血常规及血清生化指标,取主要脏器(心、肝、脾、肺、肾、脑)计算脏器指数,并进行肉眼观察和组织病理学观察。结果连续给药后,各组大鼠的饮食、体重均正常。和对照组比较,三味檀香散高、中、低剂量组除碱性磷酸酶(ALP)有明显升高(45 d)和降低(90 d)外,其余血液及血清生化指标的变化差异均无统计学意义;主要脏器均未见异常、病变或损伤。结论连续服用藏药三味檀香散较安全。
Objective To observe the long-term toxicity of Tibetan medicine Sanwei sandalwood powder to rats and provide evidence for clinical safety. Methods The rats were randomly divided into control group and high dose (15 g.kg-1), medium dose (9 g.kg-1) and low dose (1.5 g.kg-1) According to 0.1 g.kg-1) of 150, 90, 15 times, continuous administration 90 d, observe the general situation of rats, diet, body weight. On the 45th day and the 90th day of the experiment, half of the rats were killed and the blood and serum biochemical indexes were determined. The vital organs (heart, liver, spleen, lung, kidney, brain) Macroscopic and histopathological observations were made. Results After continuous administration, the rats in each group had normal diet and weight. Compared with the control group, the changes of biochemical indexes in serum and serum of Sanwei sandalwood San high, medium and low dose groups were significantly higher than those of control group (45 d) and decreased (90 d) No statistical significance; no abnormalities in major organs, lesions or injuries. Conclusion It is safer to take Sanwei Sanxiang Powder continuously.